Memory deficits are a debilitating symptom of epilepsy, but little is known about mechanisms underlying cognitive deficits. We are using physiology and multiphoton glutamate uncaging to define mechanisms that underlie altered neuronal input-output transformations. Following identification of mechanisms underlying altered integration, we are using in-vivo two-photon imaging and behavioural approaches to probe the impact of pharmacological or genetic intervention for spatial coding and memory function.